Former England striker Owen, who has scored just once for the Potters in six substitute appearances and one start, announced last week that he is to retire from playing at the end of the season.
Asked if he had any sense of regret over recruiting the 33-year-old, Pulis said: "Not at all. He has been fantastic around the place.
"He has been a great signing - if you look at it financially, it has been a great deal for the football club in lots of respects.
"Michael was really unlucky at the beginning of the season, picking up those couple of injuries.
"If he had got through that and pushed on, then we might be talking about different things now. But it is what has happened to Michael over the past few years."
Pulis has also wished Owen well in whatever he chooses to do next.
"He'll find it difficult not playing, without a question of a doubt - every footballer that has to hang his boots up will get that passion to want to go and play again," said Pulis.
"But Michael has to decide what he wants to do and then I'm sure he will give it his best, and that will be good enough, whatever career he goes into - whether it is coaching, management, if he wants to be an agent, a horse owner, whatever."