The Potters have been strongly linked with a move for the 20-year-old striker in recent weeks and now Hughes has confirmed he is looking to land the player.
"We are hopeful of progressing that," Hughes is quoted by The Sentinel.
"There seems to be a willingness from most sides.
"He's a good young player and we feel he's got potential and we would like that to happen."
Agudelo is out of contract in December and reports in America claim that he has already penned a pre-contract with Stoke.
Indeed the player has hinted that is the case, as he is quoted by the Boston Globe as saying: "Right now I'm focused on playing with the Revolution, but, I mean, everyone knows what I signed."
Hughes is hopeful of bringing in further reinforcements before the start of the season and reports in Germany claim that Stoke are in Germany to hold talks with Hannover over long-term target Mame Biram Diouf.