Glenn Whelan and Marc Wilson were both sent-off in the 5-1 defeat by the Magpies, while manager Hughes was also sent to the stands after reacting angrily at St James' Park.
Stoke are still fuming about the result and chairman Peter Coates has suggested an official complaint will be made about match referee Martin Atkinson.
Hughes has been hit with an improper conduct charge from the FA, but has turned his attentions to Sunday's trip to Tottenham and is seeking a response from his wounded side.
He told the club's official website: "We are exasperated by the events of Boxing Day, but we have another game coming our way very quickly, which I think is a good thing for us.
"Obviously we will be without a few players now, but we still have players who have the quality to go to Tottenham and cause them a lot of problems.
"It is hugely disappointing to be here now with nothing to show for our performance against Newcastle, because I really thought that there was only one team that looked like winning that game when it was 11v11, and that was us.
"It does hurt and it isn't a fair reflection of the game on our players, but we will use our frustrations to our advantage and look to get the result we want in London on Sunday."
Whelan and Wilson must serve suspensions and first-choice keeper Asmir Begovic could be sidelined for up to six weeks after breaking a finger in training on Christmas Day.
But Hughes insists his players cannot feel sorry for themselves as they attempt to pull away from the drop-zone.
"We will be without both of them. It's not ideal, but that is the way it is and we have to get on with it," he said.
"They will miss this game, as will Asmir, who looks likely to be out for between four and six weeks.
"The match will more than likely come too soon for Robert [Huth] as well, so we will have to make a couple of changes to the team."