Shawcross will become the first Potters player to reach the mark when Newcastle visit the Britannia Stadium on Saturday after being virtually ever present during their six seasons in the top flight.
Stoke boss Mark Hughes has been hugely impressed by the defender, who has been without his regular centre-back partner Robert Huth since November because of a knee injury.
But Shawcross' form has not been enough to earn him a recall to the England squad. He won his only cap against Sweden in a friendly in November 2012.
Hughes said: "He's been outstanding this year, as he has been in most seasons that he's been here. I've been really pleased with what he's produced in terms of his leadership as well.
"He's a good professional; every single day he comes in and tries to be better than the day before. He prepares correctly and that's why he's been able to bang the games out.
"He's had an exceptional season. That hasn't been recognised unfortunately by the international team, but I think that will come if he continues in the same vein.
"He certainly warrants another look. Maybe because it's a World Cup year, in certain areas the thinking is they're going to stick with what they know."
Shawcross has been linked with plenty of top teams in the Premier League, but Hughes is confident he can further his international career at the Britannia Stadium.
"He's had opportunities while being a Stoke player so it shows that's not an issue," said Hughes. "If you're playing well enough, you should get an opportunity."
Hughes welcomes back Stephen Ireland from illness and fellow playmaker Charlie Adam is also in contention despite breaking his nose in four places.
The Scot collided with reserve goalkeeper Daniel Bachman in training and is hoping to play wearing a mask before undergoing surgery on Monday.
Hughes said: "We're hopeful we're going to get some kind of protection for him in terms of a mask. He's probably got an operation on Monday but he's putting his hand up for tomorrow."