Table-topping Cardiff found themselves on the end of a surprise defeat against Brighton with Andrea Orlandi and Jose Ulloa scoring the goals in south Wales against Malky Mackay's men.
Second-half goals from Mohamed Gedo and Ahmed Elmohamady ensured Hull City claimed a 2-0 success over Michael Appleton's Blackburn Rovers.
Watford remain in third place in the standings courtesy of goals from Ikechi Anya and Nathaniel Chalobah in a 2-0 win over Ipswich at Portman Road.
Anything Gianfranco Zola's Hornets could do Crystal Palace could match as Glenn Murray and Stephen Dobbie netted in a 2-1 triumph against rock-bottom Bristol City.
Leicester City lost ground in the race for the automatic promotion places after being beaten 2-1 at home by Charlton Athletic. Chris Wood cancelled out Yann Kermorgant's first-half opener, but Danny Haynes' 78th-minute effort proved to be the winner.
The big result of the night came at the foot of the table as Barnsley came from a goal behind to beat fellow strugglers Wolves 2-1 at Oakwell. Jacob Mellis won the match in the 73rd minute.
Huddersfield, who sit just above the drop zone, have the worst goal difference in the Championship in the wake of their 6-1 drubbing at the hands of Nottingham Forest. Pole Radoslaw Majewski helped himself to a hat-trick for Billy Davies' side.
Peterborough United helped their chances of avoiding the drop with a 5-1 victory over Millwall at the Den. George Boyd pulled the strings for Posh while Millwall's night ended on a sour note as Shane Lowry saw red.
Jamie Ward ensured Derby County avoided defeat on Tuesday night as his 81st-minute effort cancelled out Richard Keogh's own goal for Bolton on the stroke of half time.
Birmingham City's clash with Sheffield Wednesday finished goalless with Nicola Zigic wasting the best chance of the game while Middlesbrough's trip to Burnley also ended without a goal.