The Sky Bet Championship leaders are hoping to register their fifth straight victory while Steve McClaren is looking to get fourth-placed County back on track after Wigan halted their seven-game winning run at the weekend.
Leicester, who boast a four-point cushion at the top of the table, led the division at the same time last year before losing out in dramatic fashion in the end-of-season play-offs to Watford.
That defeat still hurts Birchenall, who believes Friday's match gives City the ideal opportunity to bury the ghost of Vicarage Road.
"Everyone in football saw what happened that day, it was unbelievable," said Birchenall, Leicester's stadium announcer who boasts a 43-year-association with the club.
"We missed a penalty, Watford broke up the field and scored to win. It was so hard to take I don't even remember driving home that night.
"But there is a mentality about the place these days that is different from previous years and this game now gives the team the chance to put a marker down for the remainder of the season.
"It is huge for both clubs. If we win we go seven points clear - they win and they're three points closer to us. Local derbies against Derby and Forest are always huge but there is special significance on this game.
"It's on Sky Sports, there will be a full house in here so I am expecting a cracker."
And you can see who takes the honours at the Kingpower Stadium live on Sky Sports 1 from 7.30pm this Friday