Bruce can win promotion to the Premier League for a third time as manager without his Tigers side kicking a ball.
Hull are second with a four-point advantage over Watford, who are away at play-off chasing Leicester on Friday. A Leicester win will see Hull return to the top flight for the first time since relegation in 2010.
And Bruce believes the best way to get through the Friday night match is to ignore it.
"First and foremost it is a fantastic position to be in, we come down to two games left with four points in it and when it is in your hands you can't really expect not to do it yourselves," Bruce told Sky Sports News.
Bruce insists that the prospect of facing relegation threatened Barnsley is not something they are taking lightly.
"My experience with the Championship is that it doesn't matter who you play against," he said.
"I think if you look between top and bottom the points difference is remarkable, and the teams at the bottom have put up a hell of a fight, usually 50 points is enough to keep you safe but there are teams on 51, 52 and 53 still battling away so it is all to play for - but we couldn't wish to be in a better position."
Bruce is hopeful he can lead the Tigers back to the Premier League.
"We have only been there twice in the history of the club and everyone wants to be in the Premier League, that is why the Championship is so tense. But the great thing about the Championship is that it is such an even field, but the Premier League is a wonderful place to be," he said.
He praised his squad for the 'resilience' they have shown this season.
"There is a great resilience, the squad itself has been particularly consistent and we have been able to cope with injuries to Matt [Fryatt] and [Sone] Aluko particularly.
"The people we have brought to the club have settled in quickly which has helped, I hope that - fingers crossed - we get that little bit of luck and we get the performance that takes us over the line."