The Tigers were reduced to 10 men 23 minutes into a crunch clash at Upton Park, with goalkeeper Allan McGregor dismissed for bringing down Mohamed Diame after he bundled his way into the box.
To rub salt into the wounds, the Scottish shot-stopper was injured in the collision, forcing him to spend Wednesday night in hospital with damage to his kidneys.
Bruce believes the match officials, led by Mike Dean, did themselves few favours in their handling of the incident - with the punishment handed out overly harsh.
He also feels that Dean acted on impulse, after appearing to miss the challenge, and feels too many mistakes are being made by those charged with the task of making big calls.
On a setback which leaves the Tigers eight points above the drop zone, Bruce told Sky Sports: "We're hugely disappointed, but I couldn't have asked for anything more from them, they were absolutely superb on the night. With 10 men, to come to a place like West Ham, we totally dominated the game, in my opinion.
"It's too often that we stand here and criticise referee decisions, it's far too often. Sam (Allardyce) is talking about, in his programme notes today, decisions he's had in the last three games.
"We've got video evidence of the referee turning away from it, and I'm asking him 'Did he make the decision, was he listening to somebody', and he said he made the decision. When you look at him and analyse it, he's turned away from it and it's only when two players are down that he's made a decision.
"It might be the right decision, he's missed a hand-ball, but these rules are supposed to make the game fair.
"It's an innocuous challenge, he's got there first the lad, it may be a penalty, but to send him off...Is a penalty not enough? To send him off, for me he doesn't make that decision.
"It's hard enough to come to West Ham with 11, let alone 10. It's too often that we're talking about big games like this and ludicrous decisions that they keep constantly making."
Asked what can be done to eradicate the mistakes, Bruce added: "I don't know what we do, but it's got to improve.
"We come on every day and we just talk about decisions. Why can't they just have a bit of common sense?
"These rules were brought in to say that if it is blatant - Allan McGregor is in hospital in a really serious way. He's made a genuine attempt for the ball, he hasn't got it, but surely is that not sufficient? We've got somebody back on the line to clear it.
"Thankfully we still then made it a spectacle, but I think we tend to forget that there is people paying great money and there are huge big things at stake.
"For me, there is no common sense in the referees at all. They are governed by the letter of the law, to a degree, which is ludicrous in my opinion."