The Spanish striker, who has netted 13 Premier League goals since his summer arrival from Rayo Vallecano, will miss the trip to West London because of a knee injury.
Laudrup is confident Michu will be available for the game against Aston Villa next Tuesday, but the Dane has challenged his charges to prove they do not rely on one player.
"I think in a few days he could be ready but obviously for tomorrow's game he is ruled out," said the Swans boss.
"But I hope with some good work from our physios he can be back on Tuesday (against Aston Villa). If not he will be back for the week after when we have three games in six days.
"To say you don't miss your top scorer would be a lie but you can't count on one player for the whole season without him getting injured or suspended.
"I think he has played 10 or 11 games on four yellow cards. But now he is injured and out of the game tomorrow."