Referee Robert Madley's decision gave Charlie Adam the opportunity to claim a 3-3 draw for Stoke - which he duly accepted - and the pain still rankles in south Wales.
The game at Fulham this weekend is Swansea's first match in a run of fixtures which will see them play 12 games in 43 days - nine in the league, two in the Europa League and a third round FA Cup tie at the beginning of January.
"This game is up there for so many reasons, especially after what happened in the last game. We will never get those two points back," said Laudrup.
"There is not much to joke about. The memory is still there of that game. So now we start this sequence and I think this game is really important to us.
"We do not look back to the last game or any other game. This wekend is about the result for us. For me this is one of the top games of the 12 that I have mentioned.
"We have to move on and take the fantastic second-half against Stoke into the game at Fulham. We must bring the performance onto this game and get a result.
"We were all so frustrated and angry (after the Stoke game) so it would have been nice to play three or four days later so the international break maybe came at the wrong time for us."
Asked about possible transfer targets come the January window, Laudrup said that they were unlikely to do much unless players went out of the club, admitting: "I have confidence in the squad we have.
"I don't know what we will do. I don't want to comment on Tom Ince, other than the fact that he is a talented player. Gary Monk will be back in the New Year, so I don't think we we will be doing much.
"But because we have so many games, we have to be careful not to put one or two in too early. We need all of the players, especially for the coming six weeks, where everybody will play."
Swansea have won on their last two visits to Craven Cottage but will be without striker Michu and midfielder Pablo Hernandez through injury; Michu could be fit to return in the midweek game against Newcastle at the beginning of December.