The O's, who just fell short of the play-offs last term, then welcome Shrewsbury to Brisbane Road before a trip up the A1 to Stevenage on August 17.
A visit across London to Brentford comes on September 21, with the Bees making the return journey on March 15.
They will spend Christmas on the road with a Boxing Day trip to Gillingham followed three days later by a visit to Molineux to take on Wolves.
Bristol City visit on January 1 while the Easter weekend sees fixtures against Crawley away and Wolves at home.
Their final home game is against Tranmere while the season concludes with a visit to MK Dons.