De Laurentiis, who is also the owner of Napoli, apparently wants to follow in the footsteps of the Pozzo family, who own Udinese and Spanish club Granada and last year took over at Championship side Watford.
The Hornets were then controversially loaned a host of players from the two clubs, with the likes of Matej Vydra and Almen Abdi firing them to the play-off final where they were narrowly beaten by Crystal Palace.
According to the reports, De Laurentiis wants a similar tie-in with Orient, where he could send Napoli's younger players to gain first-team experience.
However, the prospect of Edinson Cavani playing up front with Kevin Lisbie at Brisbane Road next season is a long way away as things stand, after Orient confirmed there has been no contact from Italy.
However, a spokesman for the League One club added: "They are welcome to give us a call if they want to."