The Hoops scored a stunning 2-1 home success over Barcelona last November, which helped them clinch second place in Group G and a place in the knockout stages.
Wilson admits victory over Juventus and further progress in the competition would eclipse even their Catalan conquest.
"Without a doubt, if that happens," said the 27-year-old.
"It is a different situation. Obviously we needed to win to get the points but this is a knockout situation, so it would be great if we achieve it.
"This game in the Champions League is a massive one, the biggest in a lot of players' careers, myself included.
"They are two different teams. Juve are a bit more direct, Barca like to keep the ball more and in the context of it being the last-16 so they will want to get there really bad and so are we, so it will be a good tie.
"Juventus are an experienced side with world-class players. I respect them for what they have done and the players they are but I think you get on with your own game and concentrate on that.
"We are not there to make the numbers up or to say 'I played in that game', we want to try to achieve something."
Before Celtic can turn their minds to Juventus they must negotiate a tricky trip to Inverness, and Wilson says they will be professional in their approach.
"That is the first game that's coming and you have two or three days after that to think about the Juve game," he said.
"It is just as important to us because the league is what got us to where we are now so we won't take that lightly.
"You have to be professional about it, be respectful and get on with your job.
"They are a tough side, especially at home, so it will be a tough game."
Celtic could be without stopper Efe Ambrose for the Juventus match as a result of Nigeria's progression to the Africa Nations Cup final which takes place on Sunday.
Wilson believes his defensive partner would be keen to step right back into a Hoops shirt, if possible.
He said: "It is down to the gaffer but I would think Efe would want to do it because it is a massive game and what footballer wouldn't? If he didn't then maybe he shouldn't be playing football.
"I can't say if it is physically possible but Efe is not overweight or unfit so I wouldn't see why not. But it is down to the gaffer."