St Etienne defeated the Ligue 1 champions on their way to lifting the silverware last season and will have to pull off the same feat if they are to successfully defend their crown.
The clash is one of six all-Ligue 1 encounters, while Ligue 2 representation in the quarter-finals is assured after Troyes were drawn against Tours.
The last-16 ties will be played on 17-18 December.
Draw in full:
Lyon v Reims, Nantes v Auxerre, Paris St Germain v St Etienne, Troyes v Tours, Marseille v Toulouse, Evian v Bastia, Nice v Sochaux, Rennes v Bordeaux