Lille lie second in the standings, four points off the summit but on a run of form which rivals the unbeaten leaders.
It has been 10 matches since they last suffered defeat in the league, including a 1-0 win over Valenciennes at the weekend, although their title credentials will be put to the test when Marseille come to town on Tuesday.
OM are two places and five points worse off than their opponents and Lille forward Nolan Roux admits victory would be all the more sweeter if it came against a direct rival.
"There is a small amount of tiredness to contend with (after the weekend), even if it is always easier to recover from a victory," he told the club's website.
"But we will face our meeting with Marseille with great determination. And it will be amazing if we win."
Monaco are third ahead of Tuesday's derby at Nice, with five points to make up at the top and a three-match unbeaten run to protect.
With their south coast rivals suffering five successive defeats, Monaco midfielder Mounir Obbadi knows there is no better time to take the bragging rights.
"We have good momentum with our last two wins and we have the ambition," he told the club's website. "We are competitors and we want to win this derby on Tuesday.
"Our aim is to pick up maximum points before Christmas, starting with victory at Nice, but it will not be easy.
"This is a derby and we have to be fully focused."
Strugglers Valenciennes are also in action on Tuesday with a trip to Nantes, while the action continues on Wednesday when PSG will look to maintain their unbeaten campaign so far at an Evian side without a win in three.
Laurent Blanc's men hammered Lyon 4-0 at the weekend and have scored 14 goals in their last four league fixtures.
Basement side Sochaux have just one victory all season and will be desperate to double that - and bounce back from a 5-1 mauling by Toulouse - in a home match against Reims.
Ajaccio are one place better off than Sochaux on goal difference only, losing seven of their last eight games. Their next opponents are Bastia, who beat Evian at the weekend.
Bordeaux midfielder Abdou Traore will miss the trip to Guingamp after it was confirmed he will not return before the winter break because of a hamstring strain.
Fifth-placed St Etienne are the visitors to Rennes while Montpellier take on Lorient in a contest between two sides looking to pull away from the drop zone.