The Spain defender has featured for two of the world's biggest clubs - Barcelona and Manchester United - and has claimed an impressive haul of trophies during his time in the game.
He's won the World Cup, the European Championship, the Champions League (three times), La Liga (four times) and the Premier League. Not a bad effort...
Choosing the best XI of players he's played alongside would be a pretty difficult thing to do, but that's precisely what Pique will undertake on The Fantasy Football Club this week when he becomes the latest in a long line of football stars to name a #One2Eleven.
But who will make the cut? You'll have to tune in from 10pm, Thursday, Sky Sports 2 HD to find out!