The thrashing all but confirms the Spanish club's place in the quarter-finals of Europe's toughest contest and it was their star players that shone on Wednesday in Gelsenkirchen.
Bale, Ronaldo and Karim Benzema scored a brace each as a rampaging Real left the Bundesliga side requiring a miracle at the Bernabeu in three weeks' time despite Klaas-Jan Huntelaar scoring a brilliant goal in time added-on.
Madrid boss Carlo Ancelotti hailed Wales star Bale's performance as his "best game of the season". The two goals put the former Tottenham players season total at 14 goals and 10 assists in 22 games since arriving for £85.3million last summer.
Ruud Gullit told Sky Sports that he's surprised how comfortably the 24-year-old from Cardiff has settled in with his new club.
"I didn't expect Gareth Bale to settle in so well," said the Dutchman.
"I think it makes it easy for him with this team because he is surrounded by good players; I think they accepted him as a player and that's a lot easier with the amount of money he cost them.
"It took him a while and I heard he got some stick because he's injured a lot of the time, but I think that with all these good players he can be better than he was than with Tottenham."
Best in the world
Ballon D'Or winner Ronaldo showed no signs of shying away from his terrific form this season - which has seen him score 31 goals in 26 appearances - and helped Madrid make it only two wins in 26 games in Germany.
Our panel were suitably impressed...
"It's all wrong, no one should be that good," said Graeme Souness.
"What an athlete, what technique he has, what bravery he has; he is just so good at this moment in time."
Former England manager Glenn Hoddle added: "He's the best in the world at the moment; he's been voted that and I think now, he truly believes that and is going to show the world that he is.
"He wasn't always the best, I thought Messi was outgunning him for two or three years.
"But he's so determined to keep scoring goals, I think he's a wonderful player and he's the best in the world at this moment in time, there's no doubt about it.
"He's so two-footed and so strong in the air as well. He scores goals from all over the place."
What did you make of Real Madrid's brilliant performance? Are they favourites for Champions League glory? Let us know your thoughts by commenting below.