The title could be Barca's 24 hours earlier if Real Madrid fail to win at the Catalan club's city rivals Espanyol.
Real kept the title race alive with a 6-2 win over Malaga on Wednesday but have now played a game more then their title rivals as the fixture was brought forward from next weekend, when Real face city rivals Atletico in the final of the Copa del Rey.
But Busquets, who has been suffering with a groin complaint since January, is confident Barcelona can secure the championship under their own steam and will not have to rely on Espanyol doing them a favour.
Busquets told reporters: "We are ready to win the match on Sunday.
"To win a title is always special and important and the league even more. It would be the fourth league title in five years and it would be spectacular."
Busquets added: "I have no doubt that if champions, we should be celebrated with a parade through the city and a party at the stadium."
Barcelona have been close to securing the title in the last couple of weeks and Busquets is aware of the pressure created by expectation.
He added: "We have felt like this for weeks. It's the best thing to do because we deserve (the title)."
Busquets has ruled out surgery to fix his groin problem, adding: "The injury is very complicated because some days are better than others."
Pedro and Victor Valdes should be available having returned to action after missing the last game against Real Betis.
Atletico Madrid ensured they would finish no lower than third, securing a spot in the Champions League, by winning 3-1 at Celta Vigo on Wednesday.
But Atletico can also secure second spot so a win against Barcelona would be high on their agenda as well.
Real Zaragoza can improve their chances of avoiding relegation when they visit Levante on Friday.
A win would take Zaragoza up to 36 points and keep them out of the bottom three regardless of other results over the rest of the weekend.
But with Levante only nine points above the bottom three themselves they will be looking to pick up points to banish any faint possibility of dropping out of the division.
Levante coach Juan Ignacio Martinez knows a win will help his team survive the drop.
He said: "I think that 41 points is a good amount to be safe, but the teams are pushing hard behind us and we've gone several weeks without a win.
"Let's see if we can beat Zaragoza and then we can forget about all that."
Bottom side Mallorca face a key fixture away to Athletic Bilbao on Saturday knowing that even a win will not take them out of the bottom three.
Osasuna also have relegation fears but face a tough game at home to Getafe, who lie one place outside the Europa League qualifying places.
Deportivo La Coruna will also look to win and like Osasuna their focus will be on climbing away from the wrong end of the table when they face Real Valladolid.
The three teams in the Europa League places - Valencia, Malaga and Real Betis - are all in action on Sunday.
Fifth-placed Valencia visit Rayo Vallecano, Malaga are at home to Sevilla and seventh-placed Real Betis are at home to Celta Vigo, who need points as they bid to climb out of the bottom three.
Real Sociedad occupy a Champions League qualifying place and on Monday take on a Granada team needing a win to put more distance between themselves and the relegation zone.