When the dust settled on eight frantic opening minutes in St Louis, Madrid were a goal to the good. Kaka had snuck between Inter's defenders to shoot against the flicked glove of Samir Handanovic before putting his head through the rebound to make sure.
Cristiano Ronaldo then saw a close-range effort repelled by Alvaro Pereira and, at the other end, Alvaro Morata blasted over the crossbar when put through by Casemiro.
Ronaldo missed the mark with a bullet header from a corner but in the 38th minute his angled drive converted a cute through-ball from Luka Modric to give Real a 2-0 lead going into the break.
Inter's woes continued into the second half as Ricky Alvarez put through his own net from a corner on 67 minutes.
Mauro Icardi - a summer signing from Sampdoria - thought he had found a consolation for the Nerazzurri late on but his header was cleared off the line.