Premier League leaders Arsenal are the biggest drifters in the Champions League outright market after being pitted with holders and favourites Bayern Munich in Monday's draw.
The Gunners were 16/1 after settling for second place in Group F last week, but are now out to 28/1 with the Bundesliga champions unmoved at 5/2.
Manchester City were also dealt a major blow as they're up against Barcelona, with City drifting from 14/1 out to 16/1, though the Catalan giants have also lengthened from 9/2 to 5/1.
That puts fierce rivals Real Madrid ahead of Barcelona in the pecking order as they're now 9/2 second favourites having earned a favourable tie with Schalke.
Meanwhile, Manchester United have looked a different side in Europe this season and they've actually shortened from 16/1 to 14/1 as they're expected to oust Olympiacos.
Chelsea will face former striker Didier Drogba's Galatasaray outfit and have come in to 12/1 from 14/1 as they're odds-on (1/4) to qualify for the quarter-finals.
Sky Bet's Dale Tempest said: "The tie of the round has to be Manchester City against Barcelona, in what will be a huge test for both managers.
"We can't separate the sides in the betting on the first leg at the Etihad Stadium with both priced 8/5 for the win, though Barcelona are 2/5 to progress overall."