The duel between title-chasing United and defending champions City at Old Trafford will be screened live on Monday, April 8 at 8pm to conclude a gripping weekend of Sky Live fixtures from the English top-flight.
Saturday April 6 will see possible relegation rivals Reading and Southampton lock horns (12.45pm), while another match that could have a huge bearing on the drop zone will be shown on Sunday as Harry Redknapp's QPR host Roberto Martinez's Wigan (4.10pm).
During April, Sky Sports will also show the Tyne-Wear derby between Newcastle and Sunderland (12.45pm, Sat, April 13); Chelsea's game with London rivals Tottenham (4pm, Sunday, April 14); the Blues' trip to Liverpool (4pm, Sunday, April 21) and more.
Read below for the comprehensive list of our April games:
Sat April 6: Reading v Southampton (12.45pm)
Sun April 7: QPR v Wigan (4.10pm)
Mon April 8: Man United v Man City (8pm)
Sat April 13: Newcastle v Sunderland (12.45pm)
Sun Apr 14: Stoke v Man United (1.30pm)
Sun Apr 14: Chelsea v Tottenham (4pm)
Mon Apr 15: Man City v West Brom (8pm)
Sun Apr 21: Tottenham v Man City (1.30pm)
Sun Apr 21: Liverpool v Chelsea (4pm)
Mon Apr 22: Man United v Aston Villa (8pm)
Sat Apr 27: Man City v West Ham (12.45pm)
Sun Apr 28: Reading v QPR (1.30pm)
Sun Apr 28: Arsenal v Man United (4pm)