The nominees are Tottenham's Gareth Bale, Manchester United's Michael Carrick and Robin van Persie, Chelsea's Eden Hazard and Juan Mata, and Liverpool's Luis Suarez.
With Bale's 19-goal season, Carrick and Van Persie's influence on United's title winning campaign, Mata and Hazard's impressive debuts in English football and Suarez's scoring exploits, all six contenders have a strong case for being named Player of the Season.
To try and shine some light on who will get the nod at tonight's awards ceremony skysports.com spoke to three of our football experts for their view on which player deserves the accolade.
Jamie Redknapp: We've had three outstanding players in Gareth Bale, Luis Suarez and Robin van Persie this season, however, I think Bale will win it. You vote very early on for the PFA awards and because of the timing he has a really good chance - he was in such great form at that time. Consistently, all through the season right up until now it's probably been between Luis Suarez and Robin van Persie. I don't think enough fellow professionals will have voted for Suarez, though. Looking at it from a players point of view I think Bale will win it.
Paul Merson: I'd go for Robin van Persie by a million miles because he won the league for Manchester United on his own. If he had ended up at Man City they would have won the league. Forget the eight games Van Persie didn't score in - he was outstanding in the first 23 games and he's right back on form again. I don't see why Gareth Bale is such a massive odds-on favourite to win this. I just don't see it. Second maybe, but he's not the winner. Where are Spurs in the league? They're fifth! Football is all about winning trophies and medals. Without Van Persie, United wouldn't have won. I think it's a no-brainer, myself, but I doubt he will win.
Jeff Stelling: Gareth Bale. People say he's had a good few months but I don't buy that - I think he has been exceptional. He is one of the few players who can change a match on his own. He is a rare jewel of a talent - a player who can do everything. He's powerful and possesses Usain Bolt-like speed, plus he's got a lovely touch on the ball. To be frank he's got the lot and I think he'd be a worthy winner. Of the other nominees, Robin van Persie would push him closest for the title. His goals have clinched the title for Manchester United and we were all reminded on Monday when he scored that hat-trick against Aston Villa exactly how good a player he is.
Stay tuned to Sky Sports News HD tonight to see which of the six contenders lands the 2012-13 PFA Player of the Year Award.