For the first time, the NFL will play two regular season games outside of America, and it could lead to even more depending on how these games go this autumn.
First thing's first though, and both the Steelers and Vikings arrive in the UK in the unfamiliar position of 0-3 and still chasing their first win - it should make for an even better atmosphere with both teams desperate for a first win of the campaign.
Remember, catch the big game live on Sky Sports 2 from 5.30pm on Sunday.
Meet the teams
The Minnesota Vikings have made it to four Super Bowls, but lost them all! Still, they have a great tradition and also boast the league's reigning MVP in the ranks. Find out about him and the Vikings' history.
Click Here for a quick take on the Vikings.
The Pittsburgh Steelers have won more Super Bowls than any anyone else, and have a tough, gritty history both on and off the field. Up there with the best supported team in the league they've sold out every home game since 1972!
Kev and the cheerleaders
Our main man Kevin Cadle welcomes a couple of the Minnesota Vikings cheerleaders to our online studio for an exclusive chat ahead of the big game at Wembley.
We like to make Kev earn his money! So he's also been previewing the showdown between the Vikings and Steelers in his regular column. Click Here to read Kev's big game verdict.
Adrian Peterson is one of the best running backs in history and watching the reigning MVP in action is a real treat for fans heading to Wembley on Sunday. We caught up with the man himself as he prepares to face the Steelers.
It's been a relatively quiet start to the season for Peterson but he is confident he can break off some trademark big runs on Sunday if he can just stay patient.
NFL on the rise
Cecil Martin dropped in on the Sky Sports News studio to talk about the Wembley game and just how 'America's Games' continues to grow and grow in the UK.
There's now two games being played in London this year but fans seemingly still can't get enough gridiron action - Cecil believes this can only be good for the game as a whole.
This will be the seventh International Series game to be held at Wembley, and the game has now really taken off after many said that it would not be able to sustain the level of interest shown in the first one.
Here, we have a look back at the games from the first six years of the NFL at Wembley, which one was your favourite? Let us know after having a look at the full history.
NFL back in London
The flags are out on Regent Street as the NFL gets ready for the biggest street party held in the UK. Regent Street has already been decked out and on Saturday it will be a traffic-free zone for NFL fans to wander and join in the party with live music and interactive exhibitions to get everybody in the mood for the big game.
Even the players from the two teams will be out and about, while the Vikings cheerleaders and Skol drummers will be performing for fans to ramp up the excitement for Sunday's big game.
The Vikings arrived nice and early in London, and they wasted no time in heading straight to Wembley Stadium to give a workshop for local kids as they look to spread the word of American Football.
The NFL's Play 60 scheme is all about getting kids involved in sport of any variety, but the local youngsters were keen to try out their throwing arms and were delighted to see some real live NFL players in person.
It's been a long trip over, but the Vikings are enjoying their time in London, as are the travelling media who have come over to report on their team's big adventure in the UK.
We caught with Vikings beat writer Brian Murphy who had loved his early impressions of London and talked over some team issues, mainly surrounding quarterback Christian Ponder.