Gary Anderson - a runner-up to Adrian Lewis in 2011 - made light work of Mark Dudbridge in his opening match.
He faces a difficult clash against 'The History Maker' Brendan Dolan in what promises to be a tight affair, but Sky Bet still make him a 2/5 favourite with Northern Ireland's Dolan a 15/8 shot to reach the third-round.
Billericay-born thrower Kevin Painter - a 2004 finalist - dispatched Germany's Tomas Seyler 3-0 in his opening round win, finishing with an impressive 98.59 average.
He takes on 'The Asset' Paul Nicholson, who beat former World Masters finalist Stuart Kellett to set up this mouthwatering contest.
This could turn out to be quite a feisty clash and it's no surprise to see both players cannot be separated at 10/11 .
The final match of the afternoon session sees the man from Down Under Simon Whitlock take on Finland's Jarkko Komula.
'The Wizard of Oz', caned 7-3 in the 2010 final by Phil Taylor, defeated Ross Smith 3-0 in the opening round and will fancy he chances of progressing without too many problems against 'Smiley'.
He is 1/10 on to win.
Sunday evening in north London begins with Wes Newton in action against three-time world champion John Part, with eighth-ranked Newton a 1/3 favourite to beat the classy Canadian.
Huntly ace John Henderson, who ousted No 7 seed Dave Chisnall in a thriller, takes on former Lakeside champion Mark Webster in an intriguing match-up.
After his opening round win, the Scot said: "I'm coming back home and I'm taking my fiancee out for a curry and a pint of lager, actually make that champagne!"
He will hope to maintain his fine form against Welshman Webster, who has been made 4/7 favourite to knock 40-year-old Henderson out.
Last year's runner-up Van Gerwen rounds off the night with a meeting with Kevin McDine.
The Dutchman has been made 15/8 favourite to win the tournament following Phil Taylor's early exit.
'Mighty Mike' is 1/25 on to beat McDine.
The Northamptonshire thrower, who reached the Grand Slam semi-final in 2007, is a massive 10/1 shout to cause another major upset at the Ally Pally.