Injury ruled the Seasiders winger out of the previous games against Scotland, Moldova and Finland but his return to full fitness has boost head coach Gareth Southgate's options.
Liverpool winger Raheem Sterling is back with the U21s after missing the recent games against Moldova and Finland while on duty with the senior team.
Ravel Morrison, previously capped at U16, U17 and U18 level, earns recognition for
his recent performances with West Ham with a maiden call at this level.
Danny Ings gets the call after scoring 10 goals in 13 games for Burnley to help them to the top of the Sky Bet Championship and receives his first representative call-up at any level.
England travel to San Marino on October 10 before returning to take on Lithuania at Portman Road the following Tuesday.
Sterling's Liverpool team-mate Andre Wisdom starts a four-game suspension after his red card in the 1-1 draw against the Finns last month.
Arsenal defender Carl Jenkinson has been brought into the squad in the right-back's place.
Goalkeepers: Jonathan Bond (Watford), Jack Butland (Barnsley, on loan from Stoke City), George Long (Sheffield United).
Defenders: Eric Dier (Sporting Lisbon), Carl Jenkinson (Arsenal), Michael Keane (Manchester United), Jack Robinson (Liverpool), Luke Shaw (Southampton), John Stones (Everton).
Midfielders: Tom Carroll (Tottenham Hotspur), Nathaniel Chalobah (Chelsea), Will Hughes (Derby County), Ravel Morrison (West Ham United), James Ward-Prowse (Southampton), Sammy Ameobi (Newcastle United), Tom Ince (Blackpool), Jesse Lingard (Manchester United), Nathan Redmond (Norwich City), Raheem Sterling (Liverpool), Wilfried Zaha (Manchester United).
Forwards: Saido Berahino (West Bromwich Albion), Harry Kane (Tottenham Hotspur), Danny Ings (Burnley), Nick Powell (Manchester United).