Cesar Azpilicueta has been Chelsea's first-choice left-back since November, with veteran defender Cole starting just one Premier League game in the past six weeks.
Mourinho admits he is unlikely to drop the Spain international but claims 33-year-old Cole will be fresh and hungry should he get picked to represent the Three Lions in Brazil this summer.
"I'm very happy with the way Azpilicueta is performing. I cannot think about national teams at the same time as thinking about my team," the Portuguese boss told The Times.
"There are national-team managers who are very clear; they go with their players. It doesn't matter if their players are playing in the club or not. They go with their players.
"Others are influenced by whether the player is playing or not. There are different theories. There are people who like players who didn't play particularly well in the season. Why? Because they are fresher, stronger, have more energy, don't have the mental fatigue of competition, and are more ready.
"Other managers want players who perform fantastically well in the season. It's up to them."