Miller made his debut back in 2001 and has gone on to earn 67 caps for his country.
He has, however, endured a tough time on the international stage, with Scotland having taken in nine managers during his 12 years of service.
Qualification for the 2014 World Cup is now highly unlikely and Miller, who is 33 years of age, is undecided as to whether he will form part of a Euro 2016 campaign.
Now plying his trade in the MLS with the Vancouver Whitecaps, the former Rangers frontman said: "You get to 33 and that's probably another campaign away.
"It's looking highly unlikely that I'll get to a finals and that's hugely disappointing.
"Is this the end? That's something the manager will have a look at and I will as well.
"There's nothing in my career that has meant more to me than playing for my country and I am honoured to have played 67 times."