Welshman Bale was stretchered off at the end of Spurs' Europa League game against Basel on Thursday with an ankle injury, and it was initially feared that his season could have been brought to a premature end.
There was positive news on Friday as scans revealed that Bale should be back in training in a fortnight, although Tottenham will have to cope without him against Everton on Sunday.
Dembele has faith in the rest of the squad, though, saying: "Can we make the top four without Gaz? Yes, of course we can.
"There are other good players who play well. He has been very important for us but other players have to step up now."
Dembele admits it is a blow to be without Aaron Lennon as well as Bale, with the England winger also expected to be back in a couple of weeks after picking up an injury against Basel.
"Everybody knows they are two very important players for us so it's another big disappointment," said Dembele.
"But I think we have a big, good squad and we have to concentrate on beating Everton now."
Belgian midfielder Dembele is backing his former Fulham team-mate Clint Dempsey as one of the players who can make a vital contribution for the final few weeks of the season.
He said: "I remember from my time at Fulham he was very important so I know what he can do.
"He can score important goals as well. He has just come back from injury but before that he was showing some good form.
"That's the reason I have confidence - but there are other players as well."