Former TEAMtalk reporter Paul Kendrick has a young son called Joseph, who is three years old and has Non-Ketotic Hyperglycinemia, a rare genetic disorder that affects one in 60,000 new-borns.
The condition is so serious that less than 500 people in the world are living with it.
Joseph's Goal has been set up to raise funds and awareness into NKH - and little Joe was the Wigan mascot at last season's FA Cup final.
The likes of Robin van Persie, Rio Ferdinand, Theo Walcott, Jack Wilshere and Carlos Tevez have all thrown their support behind Joseph's Goal, as you can see on the website here.
Simon and James have been training for over a month now and with the big race a week on Sunday, they thought it was time to start raising some cash and awareness.
We know you all get inundated with these kind of requests, so wondered if you could afford just a donation of £6 to give a £1 for each mile.
Thanks for your time
TEAMtalk Deputy Editor