The anticipation is building ahead of tonight's titanic tussle at the Etihad Stadium, with most pundits suggesting the winner - if there is one - will go on to lift this season's Premier League trophy.
We should get hold of the team line-ups at around 7pm, when we'll discover who Roberto Mancini and Sir Alex Ferguson have put their trust in.
But before then, we thought we'd have a little fun coming up with a starting XI selected from both Manchester City and United's hugely talented squads.
We only want players who could pull on a red or blue shirt this evening, so the likes of injured defender Nemanja Vidic - who'd be one of the first names on the team sheet if fit - can't be considered.
You can choose whatever formation you want, so have a look at our team, give us your thoughts, then put your manager's hat on and pick your own.
TEAMtalk's Manchester XI (4-4-2): Hart; Richards, Kompany (c), Evans, Clichy; Valencia, Yaya Toure, Scholes, Silva; Rooney, Aguero.
Subs: De Gea, Lescott, Young, Carrick, Nani, Welbeck, Balotelli.