The former Tottenham boss will be revealing his team on August 13, pitting his Premier League dream team against those looking to land over £100k in prizes.
Redknapp has been trawling the transfer market over the summer to put together his perfect starting XI from a £75m budget which will compete with over 500,000 players.
"Team selection in one of the most important decisions a manager makes, each week you have to pick the right team for the job at hand and sometimes that means leaving out your best players.
"Managers need to consider a player's form, fitness and record against the opposition when choosing a starting 11, but sometimes you've just got to go with your gut."
He continued: "Sky Sports Fantasy Football is a great opportunity to put theory into practice; do you have an eye for the in-form players? Can you follow your head and not your heart?
"I'll be putting my experience to the test and I want to wish good luck to all those that think they have what it takes."
Pick your Sky Sports Fantasy Football team here.
Fantasy fanatics can take on Redknapp in his own free to enter Public League - Harry's League. You can enter with two different sides in the free-to-play game, utilising the five different formations available and handing the captain's armband to your star man.
For those still unsure on their selections, unlimited transfers are available until the start of the season, while another 30 are available during the campaign.
Help is also on hand in the form of the new Fantasy Football Club show, which will air every Friday from 10pm-11pm on Sky Sports HD, hosted by Fenners and Paul Merson.
Every week the show will feature special guests, discussion of key fantasy football issues, analysis of fantasy football teams, guest interviews and much, much more.
To find out more about the show follow @FantasyFC on Twitter.
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