Liverpool have a number of injury concerns to contend with before Brendan Rodgers finalises his line-up.
Defensive duo Toure and Aly Cissokho and midfielder Joe Allen picked up injuries during the midweek Capital One Cup win over Notts County.
If Toure fails to recover from his groin problem Liverpool are hoping that Martin Sktrel will recover from a knee injury to take his place alongside Daniel Agger in the heart of their defence.
Luis Suarez remains absent for Liverpool as he serves the eighth game of his ten match ban meaning the in-form Daniel Sturridge will continue to lead the attack.
Sebastian Coates is a long-term absentee for Liverpool as he recovers from a cruciate knee injury.
United are without Wayne Rooney after the striker sustained a head injury during a collision with a team-mate during training on Saturday afternoon.
Phil Jones is expected to shake off a back injury he picked up against Chelsea to start at right-back in place of the injured Rafael.
United boss David Moyes has no other injury concerns to deal with as he prepares for his first experience of Manchester United versus Liverpool at Anfield.