The 18-year-old has reportedly attracted interest from the likes of Arsenal, Chelsea, Barcelona and recently Manchester City, with rumours Roberto Mancini will launch a £10million bid, and then loan Hughes back to Derby.
And Clough knows, as much as he would like to keep his best players, with the club in the financial predicament they are in, he would be powerless to prevent his prized possession from moving on.
"If somebody blows us out of the water with a massive offer then he will go, but that is the same at any club,'' Clough told the Daily Star.
''Every player has his price, in any league, but we will always try to keep our best players.
''Our aim is to get into a position financially to hang on to them."