The Manchester United and Liverpool strikers - the top two goal-getters in the Premier League - go head-to-head on Sunday.
bet365 spokesman Steve Freeth said: "The pair are in scintillating form and they look set to dominate the Golden Boot market for the rest of the season with a 50 goal haul looking well within their compass."
The Dutchman is 6/4 to outscore Suarez on Sunday and bet365's 5/4 favourite to end 2012/13 with another Golden Boot.
2012/13 Premier League
Combined 2012/13 PL Goals Total Of RVP and Suarez
Under 49.5 11/10 Over 49.5 4/6
(Currently have 31)
2012/13 PL Top Scorer
Robin van Persie 5/4 Luis Suarez 9/4
Demba Ba 9/1 Miguel Michu 14/1
Sun 13th Jan - Man Utd v Liverpool
Who Scores Most Goals
Robin van Persie 6/4 Tie 11/10 Luis Suarez 7/2
(Both must start)