New manager David Moyes takes his team to the Liberty Stadium on 17 August just a few days after a United select XI will meet Swansea in a testimonial for Alan Tate.
United then welcome Chelsea to Old Trafford in Moyes' first competitive home match in charge before travelling to old rivals Liverpool before August is over.
The first Manchester derby of the season comes at the Etihad Stadium on 21 September, which is the fifth game of the campaign, while the Red Devils tackle north London duo Arsenal and Tottenham Hotspur in November.
Moyes will face his former club Everton for the first time at home on 3 December, with the return visit to Goodison Park scheduled for 19 April.
The Christmas period sees United travel to promoted Hull City on Boxing Day and Norwich City two days later, before welcoming Tottenham on New Year's Day.
March opens with the second Manchester derby and United will also tackle Liverpool at home that month.
The season concludes with a trip to Southampton on the final day, which is preceded by home games against Norwich and Sunderland.