Robin van Persie has been sidelined for five games with a thigh injury, while Wayne Rooney missed the 1-0 win over Norwich last time out with a groin problem.
Wednesday's visit of Tim Sherwood's side will come too soon for the Dutchman, while Rooney faces a late fitness test.
"We'll need to wait and see with Wayne," Moyes told reporters at his pre-match press conference.
"He didn't train (on Monday) so we'll assess it and see how he is.
"Robin's not quite ready but we hope he'll not be too far away."
Though Danny Welbeck has profited in Van Persie's absence, his winner at Carrow Road a fourth goal in five matches, injuries to key players have sharpened the focus on potential new arrivals.
Moyes has been linked with two key men at former club Everton in Ross Barkley and Leighton Baines but admitted the January transfer window was a tricky time to recruit.
"We'll always be looking to add players if we can but I've said before, I'm not sure that January's a brilliant month to do business," Moyes added.
"It is not normally a month when the players you would choose to get will be made available by their clubs. I won't do business for the sake of it."
Victory against Spurs would extend a winning run to seven matches but the Scot played down his side's recent upturn in form.
"I don't think anyone's jumping up and down because we've won six games in a row - it's expected here," he said.
"Tottenham are difficult opposition. They've either been in the Champions League or they've been pushing for the Champions League and have always been a good, strong team."