In a tough start to the season for City, they also face Manchester City and Arsenal in their first five games.
The club's first home game is against Crystal Palace, although they do not then face another promoted club until December.
October provides a trip to Old Trafford to face champions and Hughes' former club Manchester United.
Stoke play Newcastle United at St James' Park on Boxing Day and two days later they face Tottenham at White Hart Lane.
Stoke open their 2014 fixtures against Everton at home.
From the start of February, they face a tricky five-game period including matches against Manchester United, Manchester City and Arsenal.
The season closes with games against Fulham at home and West Brom away in May.