The Black Cats sunk to a 3-1 defeat at bottom club QPR to become embroiled in the struggle for survival.
But Belgium goalkeeper Mignolet is convinced Sunderland's home form will garner enough points to hit the magical 40-point mark before the current campaign ends.
"We have to look forward and it is important we do that rather than talk about the last couple of games," he said.
"It is important to look upwards and ourselves, to make sure we are ready for the game. We can still end up where we want to be - there's a lot still to play for.
"There's three points up for grabs this weekend and we need to make sure we (get them) and then end the season on a high."
Manager Martin O'Neill has highlighted the importance of getting back to winning ways as soon as possible and Mignolet added: "We have to make sure we're up for it.
"At home, with the crowd behind us, we can get the three points... We can't over-think things. The solution is within ourselves. We need some wins and we have enough ability in this squad to make it happen."