Barca will be formally presented with the Primera Division trophy after the match, but, even with the silverware secure and the celebrations planned, forward Pedro has told his team-mates to keep focused as they bid to reach a landmark 100 points by the end of the season.
They go into the game on 91 points, with nine more available, so there is no room for any slip-ups the rest of the way.
"The 100-point mark is a big motivation for us and that is the objective we have in mind," Pedro told a press conference.
"We know it will be difficult because the teams we meet still have things to play for, but we intend to try.
"The league is the most important title in any season because it reflects your consistency. I'm very pleased about the league title and the work the team have put in. Personally I would have liked to have given a bit more to the team, but I'm happy with the chances I was given."
Although the players have given themselves one final objective for the campaign, much of the talk surrounding the club has already turned to the future, and specifically whether or not Brazilian star Neymar will be among the summer acquisitions.
Pedro deflected the speculation about a player who would threaten his own place in the side.
"It's normal there is talk of reinforcements," he said. "Barca need goals and attacking contributions and that's why every year the forward line is changed.
"My intention is to stay here and be a part of this great club. The decision isn't down to us, but I hope to get back and feel good again and bring more to the team next season.
"Neymar is a great player. If he comes here it'll be great for the team because it will make us even stronger. It means there would be more competition up front, but that's good to keep on learning. I hope he comes! He'll fit in well here."
Valladolid are safely in mid-table, but still have an outside chance of securing a European berth. They sit 12th, four points shy of Sevilla in eighth, which will bring a Europa League place assuming Malaga are unsuccessful in their bid to have their European ban overturned by the Court of Arbitration for Sport.