After failing to make the breakthrough before half-time, PSV needed just three minutes of the second period to get their noses in front thanks to Florian Jozefzoon.
Oscar Hiljemark quickly added a second before Memphis Depay completed the 3-0 scoreline in the 83rd minute to leave last season's runners-up at the top of the standings.
Level on nine points with PSV are PEC Zwolle who claimed an impressive 5-1 victory away to NEC on Saturday.
All five of Zwolle's goals came inside the hour with Kamogelo Mokotjo (18 minutes and 52) and Fred Benson (37 and 49) netting braces after Jesper Drost (15) had opened the floodgates. NEC's only consolation came from Christoph Hemlein's 76th-minute strike.
FC Groningen would have joined PSV and Zwolle on nine points if they had beaten Cambuur Leeuwarden but they were on the wrong end of a 4-1 scoreline.
Michiel Hemmen set the home side on their way with a second-minute opener and Erik Bakker and Ramon Leeuwin added further goals to make it 3-0 at half-time.
Groningen pulled a goal back in the 50th minute through Michael De Leeuw but Wout Droste's 69th-minute effort ended any thoughts of a memorable comeback from the visitors.
AZ Alkmaar, the 2009 Dutch champions, beat RKC 2-1 away from home with Maarten Martens (84) scoring the winner just seconds after Jean-David Beauguel had equalised for the hosts. AZ had earlier taken a fourth-minute lead through Aron Johannsson.
Today's other match saw Roda JC draw 1-1 at home with Vitesse Arnhem, Valeri Kazaishvili putting the visitors ahead in the 62nd minute only to see Marc Hocher draw Roda level seven minutes later.