The Light Blues extended their lead to 15 points on Saturday with their 10th consecutive win.
However, the 1-0 victory over 10-man Queen's Park came courtesy of an injury-time goal by Fraser Aird and Rangers travel to Annan's artificial pitch on Wednesday, where they drew 0-0 in September.
And McCoist believes self-motivation will keep the players going, despite the apparent inevitability of them securing the title.
The Ibrox boss said: "In terms of motivation, it will not be a problem because the players will be seriously motivated to go out and win games no matter who the opposition are.
"We have never had a problem with motivating players here and that's one of the issues you have to accept when you become a Rangers player.
"If you've got to find motivation, then you've got a problem because you have to win every game here.
"We saw what it was like at the start of the season when we weren't being just as successful away from home.
"Maybe there was a little bit of an overreaction but that overreaction is always there when you don't win games at Rangers."