Danny Welbeck's absence through suspension created a vacancy from the team that defeated Moldova on Friday.
And, as he did against Moldova, Hodgson went for the additional defensive capabilities of Milner on the England left rather than the more attacking option of Ashley Young or untested Tottenham man Andros Townsend.
With the remainder of the England side remaining the same, it meant Frank Lampard became the eighth player to reach 100 caps.
At the head of Group H on goal difference from Montenegro, who are not in action this evening, victory would also take England four points clear of Ukraine with just two games remaining.
Whilst a point would not represent a bad evening's work, defeat would leave England facing a play-off at best, with Ukraine able to hold them off with maximum points next month even though the remaining matches for Hodgson's men are both at home, against Montenegro and Poland.
England team to play Ukraine in the World Cup qualifier in Kiev: Hart; Walker,
Jagielka, Cahill, Cole; Walcott, Lampard, Wilshere, Milner; Lambert.