Doyle has scored twice in six games for the Championship side and was due to spend the rest of the season at the Loftus Road club.
However, the Republic of Ireland striker has been sent back to Molineux as the 30-year-old is unlikely to fit before the end of the season.
"Kevin's injury is long term and he's gone back to Wolves," confirmed QPR manager Harry Redknapp.
"He's tweaked his knee ligament and he's certainly going to be out for at least six weeks. It's a long job, unfortunately."