Ayew's brother and Marseille team-mate Andre is included in the 26-man travelling party which will compete for continental glory in South Africa.
Jordan Ayew is understandably disappointed to have been overlooked, but is looking to take the positives from his omission.
He said: "I am disappointed but Marseille will gain from this, because they need me in January.
"I wish Ghana good luck and hope my brother comes back to Marseille in February with a medal."
Only four players currently plying their trade in Ghana have been called upon by coach James Kwesi Appiah.
The majority of the squad ply their trade in Europe, with the likes of John Paintsil, Christian Atsu, Kwadwo Asamoah and Anthony Annan adding vital experience.
Bristol City winger Adomah will also be involved, with the 24-year-old eager to add to the three caps he has won to date.
Ghana's 26-man squad for the 2013 Africa Cup of Nations:
Goalkeepers: Adam Kwarasey (Stromsgodset, Norway), Fatau Dauda (AshantiGold, Ghana), Daniel Adjei (Liberty Professionals, Ghana)
Defenders: John Paintsil (Hapoel Tel-Aviv, Israel), Harrison Afful (Esperance, Tunisia), Mubarak Wakaso (Espanyol, Spain), Richard Kissi Boateng (Berekum Chelsea, Ghana), John Boye (Rennes, France), Jonathan Mensah (Evian, France), Isaac Vorsah (Red Bull Salzburg, Austria), Jerry Akaminko (Eskisehirspor, Turkey), Rashid Sumaila (Asante Kotoko, Ghana), Awal Mohammed (Maritzburg United, South Africa).
Midfielders: Andre Ayew (Marseille, France), Christian Atsu (FC Porto, Portugal), Anthony Annan (Osasuna, Spain), Derek Boateng (Dnipro, Ukraine), Solomon Asante (Berekum Chelsea, Ghana), Emmanuel Agyemang Badu (Udinese, Italy), Kwadwo Asamoah (Juventus, Italy), Albert Adomah (Bristol City, England), Rabiu Mohammed (Evian, France)
Forwards: Asamoah Gyan (Al Ain, UAE), Emmanuel Clottey (Esperance, Tunisia), Richmond Boakye Yiadom (Sassoulo, Italy), Yahaya Mohammed (Amidaus Professionals, Ghana)