Hodgson's side secured their qualification for Brazil last month with victory over Poland and he is expected to name a much-changed side for the frendly with Chile on November 15, with a stronger outfit likely when Germany arrive at Wembley four days later.
Andros Townsend will get another opportunity to impress having played so well against Montenegro and Poland, while Chris Smalling and Daniel Sturridge are likely to start against the South Americans.
Skipper Steven Gerrard may only play a bit-part due to a hip problem, while Michael Carrick has a calf injury, leaving Hodgson with the perfect chance to take a closer look at Everton midfielder Ross Barkley.
Danny Welbeck has been carrying a knee injury while Alex Oxlade-Chamberlain and Theo Walcott are not yet back to full fitness, so West Ham youngster Ravel Morrison, Raheem Sterling and West Brom's Saido Berahino are all in contention for a call-up.
Hodgson may also choose to hand Celtic keeper Fraser Forster his international debut ahead of Joe Hart, although he is likely to be without Jack Wilshere, who is struggling with an ankle injury.
And Sky Sports pundit Phil Thompson feels picking Forster would be the right decision, despite Hart needing a 'confidence booster' in the wake of his recent benching by Manchester City boss Manuel Pellegrini.
"Joe Hart has got the spot nailed on and he will come back into the side. If you were a few more months down the line and Joe's not played, you would have to play him in these sort of games," Thompson said.
"Forster at Celtic has to have the opportunity. He's had the experience of the Champions League and I think he needs to get these two games for England.
"It will be difficult for Joe because he needs a confidence booster but he realises he is still the No 1, and as a manager Roy Hodgson has to tell him that, but these players have to be given a chance."
You can see Roy Hodgson's lunchtime press conference live on Sky Sports News from 12.30pm