The pair have plundered 22 goals between them this season, making them the most productive attacking unit in the Premier League.
Negredo has hit the ground running following a summer switch from Sevilla, while Aguero has returned to top form following a frustrating 2012/13 campaign.
A shared language has helped the duo to flourish, but both are also fluent in the art of unlocking defences.
Negredo said of the understanding they share: "It's been good from day one and with both of us speaking Spanish, we understand each other.
"He's a great player, and with great players it's easy to get along.
"From the first moment we did well together and when we play, we understand one another."
Negredo netted his first City hat-trick in a 5-2 UEFA Champions League demolition of CSKA Moscow on Tuesday, while Aguero was also on target against Russian opposition, and club colleague Samir Nasri believes the Blues have found themselves the perfect strike attack.
The French playmaker said: "For me, Negredo and Aguero are really complete together.
"One is small, quick, has good feet, while the other is just a beast.
"He can keep the ball, score goals and in the last few games, they've banged in goals for fun."