The Spain international took his goal tally for the season to 18 as he played a starring role in City's 6-0 victory in the first leg of their Capital One Cup semi-final at the Etihad Stadium.
Negredo, who joined City from Sevilla for £20million last summer, said: "I'm in a great moment and I hope to have better than this but, yes, my feelings and my game make me think this could be the best moment.
"Well we have a big squad and the team has lot of confidence to win things here.
"A game like this requires a lot of intensity and control of the game, but we know that if they want to beat us at home the other team has to play really well."
Negredo has linked up well with Edin Dzeko in the absence of the injured Sergio Aguero for the past month and he is enjoying his partnership with the Bosnian.
"It's been really good," the 28-year-old said. "With great players it is very easy to play, we are always looking for each other.
"The partnership is working very well. He gave me a great assist and we always look after each other, and that's the important thing and it is best for the team, whoever plays."