Ozil, who joined from Real Madrid for £42.5m in the summer, was vilified by some supporters for his part in Saturday's Premier League humiliation at Anfield, notably for giving the ball away in the build-up to the third and fourth goals.
Wenger said: "It's always a disappointment to lose a game but we've been very stable defensively; we'd just been on a 10-game unbeaten run so you can't see one game as a trend. It's down to the team to respond in a positive way.
"Mesut Ozil? He was like everybody on Saturday - he was not in a good day. There's nobody really to ostracise from that game - we are just conscious we were not good enough.
"He didn't have the best of games, but that can happen. He works very hard to adapt to the physical level of the Premier League and for me he is an exceptional player.
"I wouldn't like to put too much pressure on him because he has been a top-class player until now. He knows when he is not good enough he will get questioned - that is normal."
While many have seen this defeat at Anfield as a sign of an impending collapse, Wenger is adamant a convincing performance against Manchester United on Wednesday night will help restore harmony.
"Let's not forget we played some convincing games against Liverpool, Tottenham, Napoli and Dortmund," he said.
"Winning the Premier League will be a big achievement when we do it, but we have a long way to go.
"We've been very stable until now defensively. We have to consider how well we have done until now.
"We tend to forget how good we are when you are not successful. We have worked very hard until now. These players deserve success.
"I think the Liverpool game was an accident and we want to treat it like that. We have no injuries from Saturday and we have Sanogo available again.
"We will respond tomorrow (Wednesday) in a very positive way, I'm convinced of that. We know our form at the Emirates will be decisive."
Really? Ozil came to Arsenal to be judged less? Despite his club record fee by a country mile and being acknowledged undoubtedly the best player at the club instead of being behind Ronaldo and Bale in the superstar stakes at Madrid? Ahhh he must be going for that hiding in plain sight idea. He always is going to be a defensive liability but a player as talented as Ozil you can make allowances for if he is going to make a difference at the other end (funnily enough we did the same for Pires and even Thierry to an extent). Petulant he may be, and being embarrassed after a defeat isn't a slight on the fans or disrespectful to the club; if anything it shows he cares. Arsenal have a way of operating that isn't the norm for many clubs (applauding the fans regardless of result being one). If it happens again then I would reconsider my opinion but quite frankly most Arsenal fans seem to change their opinions more often than Jordan changes her relationship status. This guy has gone from hero worship to some kind of maniacal egotist within 6 months- cresentio