The German champions hold a 2-0 lead going into Tuesday's second leg at the Allianz Arena following their first-leg win in London.
In the first leg, the Gunners were the better team in the opening stages and would have taken the lead but for Manuel Neuer saving a penalty from Mesut Ozil.
Bayern also missed a penalty, but in conceding the spot-kick Arsenal keeper Wojciech Szczesny was sent off and the away side then made their numerical advantage count with goals from Toni Kroos and Muller giving them a firm grip on the tie.
But Muller is not underestimating the threat posed by Arsene Wenger's side.
"We have to be physically strong," said Muller. "In London in the first quarter they were much stronger than us, especially in the one on ones, especially with the balls in the air. They went right for goal.
"We have to make sure we are right there with the one-on-ones against them and when we have the ball we control the ball.
"Controlling the ball is our strength; we make sure we control the game that way. We have to make sure Arsenal can't get into a position when they can really control the games themselves."
Muller is also certain the character of his side will ensure they are not complacent on Tuesday night.
"When I think of the character of the team, it can't really be dangerous for us," he added. "If I look at the Bundesliga games - I think the last 15/16 games we've won and it's been clear that we'd always win.
"If you look at some games now it could be a difficult time after an international and Champions League game maybe you're not concentrated but it's always happened.
"It doesn't matter what game it is, we've always wanted to win. We are not careless or arrogant we are extremely dominant, especially against the ball and that shows what we can do and what results we can achieve."