The Gunners have often been forced to cash-in on their leading stars, with Cesc Fabregas, Robin van Persie, Samir Nasri and Emmanuel Adebayor all lining up against them in the Premier League this season.
But Wenger feels the tables are starting to be turned, with his side able to secure high-profile signings Mesut Ozil and Alexis Sanchez over the last 12 months, with the promise of more to come.
"We are less vulnerable now, that is for sure," Wenger said.
"In the last two years we bought Ozil and Sanchez - five years ago we would have lost Ozil and Sanchez.
"We have more money available to buy today than we had five years ago.
"We can compete better. For years we have lost top players without the ability to replace them because of financial management."
As well as Sanchez, Arsenal have spent £16m on 19-year-old defender Calum Chambers, who became the latest in a long line of players to leave Southampton this summer.
And Wenger compared Arsenal's past difficulties to the current situation at St Mary's, where Alex Oxlade-Chamberlain, Theo Walcott and Gareth Bale have also departed in recent years.
"It is tiring to lose players - whether it be to Man City or somewhere else - it is the same," Wenger added.
"Southampton would say the same today. If you look at the team Southampton had last year and then add Oxlade Chamberlain, Walcott and Gareth Bale you see the quality of the work they have done.
"They are in a similar position today to where we were before in relation to the other clubs who have superior financial power."
"I don't think it's bullying - a transfer is an agreement between three parties and they are in a position where they can say no.
"The players end up at the richest clubs. Man United did that for years - they had superior financial power and they still do."
Wenger feels bigger clubs are increasingly coming under pressure from UEFA's Financial Fair Play regulations, which inhibit a club's ability to spend more than they earn, but he also believes there are loopholes to be exploited.
"It looks like they have some restrictions but they have clever people who can think about how to get around them and they do that very well," Wenger said.
"Time will tell. UEFA have to be cautious as well because of television financial power.
"If you kick a club like Paris Saint-Germain out tomorrow, the French television companies will go to UEFA and ask for their money back. It's not as easy as it looked at the start."